I want to calculate an equation within a controller(Arduino)
y = -0.0000000104529251928664x^3 + 0.0000928316793270531x^2 - 0.282333029643959x + 297.661280719026
Now the decimal values of the coefficients are important because "x" varies in thousands so cube term cannot be ignored. I have tried manipulating the equation in excel to reduce the coefficients but R^2 is lost in the process and I would like to avoid that.
Max variable size available in Arduino is 4byte. And on google search, I was not able to find an appropriate solution.
Thank you for your time.

As far as I understand the Arduino specifications, the number $-0.0000000104529251928664$ will be rounded to approximately $-0.00000001045293.$ In scientific notation, that's $$ 1.045293 \times 10^{-8}. $$
You'll lose some precision because only four-byte floating-point numbers are supported, but you won't lose the $x^3$ term completely. In fact it will be very nearly as accurate (relative to its mathematically correct value) as any of the other terms.
On the other hand, what happens to $R^2$ if you divide the $x$ coordinate of every data point by $2000$ and use the equation \begin{multline} y = -83.6234015429312 x^3 + 371.3267173082124 x^2 \\ - 564.666059287918 x + 297.661280719026? \end{multline}