A set $S \subset \omega_1 \times \omega$ is a large rectangle if $S = A \times B$ where $A$ is uncountable, and $B$ is infinite.
Assuming the continuum hypothesis, is there necessarily a set $T \subset \omega_1 \times \omega$ such that every large rectangle intersects both $T$ and its complement?
Yes this is true. Let $T_{\alpha}\subseteq \omega$ be a family of sets and define $T=\bigcup\limits_{\alpha<\omega_1}\{\alpha\}\times T_{\alpha}$. We want the sets $T_{\alpha}$ to have the property that for each infinite $B\subseteq\omega$, $$B\cap T_{\alpha}\neq \emptyset$$ $$B\cap (\omega - T_{\alpha})\neq \emptyset$$ both hold for all but countably many $\alpha<\omega_1$.
Such a family can be constructed using CH, as follows, let $B_{\alpha}$ be an enumeration in order type $\omega_1$ of all infinite subseteq of $\omega$. To define $T_{\beta}$ we need only a set such that
$$B_{\alpha}\cap T_{\beta}\neq \emptyset$$ $$B_{\alpha}\cap (\omega -T_{\beta})\neq \emptyset$$ For all $\beta<\alpha$.
This is easy to accomplish let $B_i:i<\omega$ be an enumeration of the sets $B_{\alpha}$ for $\alpha<\beta$ and for each $i$ chose $x_i,y_i\in B_i$ and place $x_i\in T_{\beta}$ and $y_i\in \omega-T_{\beta}$. Thus at any stage there are a finite number of forbidden $x_j$ and $y_j$'s but as $B_i$ is infinite a choice always exists. This constructs $T_{\beta}$ and thus $T$.