The most famous large number that have appeared in mathematical papers is the Graham number. However, the Graham number is an upper bound, and its largeness has no meaning.
I would like to know about huge numbers that have deep mathematical meaning.
What are some mathematically significant numbers that are larger than a billion?
For example, the order of the monster group.
UPDATE:
Since the Mersenne primes are an important but prime set, it seems obvious that large ones exist. I want you to name a single number.
Numbers that have no eye-catching features other than size are not included.
Artificial numbers such as "pi times a billion" are excluded.
The Fermat number $F_5$ is certainly important, but I am looking for numbers that has important points outside of its historical context.
Littlewood proved that, contrary to then popular belief, there were infinitely many integers $n$ such that there were more primes less than $n$ congruent to $3 \pmod{4}$ than to $1$.
The first such $n$ (which I do not know, but which is probably known) would be an answer to this question.
This abstract of Carter Bays and Richard H. Hudson's On the Fluctuations of Littlewood for Primes of the Form $4n \pm 1$ suggests some other candidates.
On the same topic, from the same paper, reported in Wolfram