$I =\displaystyle\int \dfrac{\sqrt{4+9x^4}}{x^3}dx$
One method we have tried is to use the substitution $x^2=\displaystyle\frac2{3\tan\theta}$ ,but it seems hard to change back the $\theta$ to x in the answer.
Update:
My answer using the substituion $x^2=\displaystyle\frac2{3\tan\theta}$
$I =\displaystyle\int \dfrac{\sqrt{4+9x^4}}{x^3}dx$
$=\displaystyle\int {\sqrt{4+9(\frac{4}{9\tan^2\theta})}(\sec^2\theta)(-\frac{3}{4}) d\theta}$
$=\displaystyle-\frac{3}{2}\int {\sqrt{\frac{1+\tan^2\theta}{\tan^2\theta}}\sec^2\theta d\theta}$
$=\displaystyle-\frac{3}{2}\int {\frac{\sec^3\theta}{\tan\theta}d\theta}$
$=\displaystyle-\frac{3}{2}\int {\frac{\sin\theta}{\cos^2\theta\sin^2\theta}d\theta}$
$=\displaystyle-\frac{3}{2}\int {\frac{\sin\theta}{\cos^2\theta(1-\cos^2\theta)}d\theta}$
$=\displaystyle-\frac{3}{2}\int {\frac{1}{(1-t^2)t^2}(-dt)}$ by letting $t=\cos\theta$
$=\displaystyle\frac{3}{2}\int \big({\frac{1}{1-t^2}+\frac{1}{t^2}\big)dt}$
$=\displaystyle\frac{3}{2}\int \big[\big(\frac{1}{2})({\frac{1}{1+t}+\frac{1}{1-t})+\frac{1}{t^2}\big]dt}$
$=\displaystyle\frac{3}{4} \big(\ln({1+t})-\ln({1-t})-\frac{2}{t}\big)$
$=\displaystyle\frac{3}{4} \big(\ln({1+\cos\theta})-\ln({1-\cos\theta})-2\sec\theta\big)$
and then substitute back $\displaystyle\cos\theta = \frac{3x^2}{\sqrt{4+9x^2}}$ into the answer
Let $x^2=u\implies dx=?$
$$I=2\int\dfrac{\sqrt{4+9u^2}}{u^2}du$$
Now integrate by parts $$I=2\sqrt{4+9u^2}\int\dfrac{du}{u^2}-2\int\left(\dfrac{d\sqrt{4+9u^2}}{du}\int\dfrac{du}{u^2}\right)du=?$$