Application of Ito's Lemma to stochastic integrals

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From my understanding, the Ito Integral is a random variable itself. Suppose we have $X_t=\int_0^t Z_udZ_u$. To find $dX_t$, I would think we can apply Ito's Lemma. However, how would the partial derivatives with respect to $t$ and $Z_t$ work?

Any comments are appreciated. Thanks