Let the set $S$ be initially empty.
In one step you can partition $\mathbb R$ into two sets $A, B$ and add $A\times B$ to $S$.
Can you make so that $S = \mathbb R^2\setminus\{(x,x):x\in\mathbb R\}$ in countably many steps?
Of course, there is nothing special about $\mathbb R$ but it's cardinality in this problem, so feel free to change it to $\mathcal P(\mathbb N)$ or $\{0, 1\}^\mathbb N$.
My guess is that it is possible. No clue on how to approach it, though.
I don't really have a motivation for this one. I just have been questioning a lot of things about $\mathbb R$ lately.
For every rational number $q$, add $(-\infty,q] \times (q,\infty)$ and its mirror image $(q,\infty) \times (-\infty,q]$ to $S$.
This does the job: