Calculating percentage of a profit

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399 is the amount you will gain if you invest 345

Therefore profit is 399 - 345 = 54

I want to express profit as percentage of the amount that you'll get back but I'm not sure why 2 methods give different results and what's the meaning of another one.

Method 1:

399 / 345 = ~1.15 meaning profit is 15%

Method 2:

345 / 399 = ~0.86 meaning profit is 1 - 0.86 = 14%

Which of the 2 methods is correct to express profit as percentage and what does the other method mean?

For instance I want to be able to avoid investment unless I'll profit 20% on top of invested amount.