Let $f:\mathbb R^n\to\mathbb R ^n$ be a continuously differentiable function with nowhere singular differential. Can there exist a set of non-zero measure $A$ such that the measure of $f(A)$ is zero?
The inverse function theorem rules out simple examples like an $f$ that maps a disc to a line segment, but it leaves open the possibility of an $A$ with non-zero measure but empty interior. For example, could there be a smooth function on $[0, 1]$ mapping the irrational numbers to the Cantor set?
Let $S$ be a set with nonzero measure. Then $S \cap K$ has nonzero measure for some compact $K$ and thus we can assume that $S$ itself lies inside an compact set. By compactness we can also assume that $f$ is injective.
Since $f$ is $C^1$ there are constant $c, C$ so that $$ 0< c\le |\nabla f(s)| \le C$$ for all $s\in S$. Thus we have
$$ C^{-1} |f(S)|\le |S| \le c^{-1}|f(S)|.$$
This implies in particular that $f(S)$ also has non-zero measure.