A quick check shows this to be true for all odd numbers less than 4495, can it be shown for all odd numbers? Is this a known result?
Here is the PARI program I used to check:
x=[]; forprime(p=3, 100, forprime(q=3, 100, forprime(r=3, 100, forprime(s=3, 100,
if(2*p*q-r*s>0 && p!=q && p!=r && p!=s && q!=r && q!=s && r!=s, x=setunion(x, [2*p*q-r*s])) ))));for(i=1, length(x), if(x[i]<5000,print(x[i])))
The first odd number that fails in this check is $4495$.