An entry of an $n \times n$ matrix with nonzero determinant is defined as interesting if by changing this entry (and only this entry) the determinant of the matrix can be made $0$.
Is it true that each entry of every matrix with nonzero determinant is interesting?
Is it true that there is an interesting entry in each row of a matrix with nonzero determinant?
Your question 1: Let us consider an entry $a$ of a matrix $M$; if its cofactor (or minor) is non zero, it is automatically "interesting" because the determinant of $M$ is a first degree polynomial $ua+v$ in this entry with $u \neq 0$. It suffices then to take the value $a=-v/u.$
An example among billions:
$$\det\pmatrix{5&-3&-2\\8&-5&-4\\a & 3&3}=9+2a \ \ \text{with cofactor} 12-10=2.$$
Thus, in a rather vast majority of cases, any entry is "interesting".
Your question 2: Yes necessarily, because if all the cofactors of a certain row are zero, the determinant itself is zero ; contradiction.