The set $M$ consists of 2001 distinct positive integers, none of which is divisible by any prime $p > 23$. Prove that there are distinct $x, y, z, t \in M$ such that $xyzt = u^4$ for some integer $u$.
I guess some kinda Pigeonhole Principle argument should be useful, but I can't figure it out.
Not an answer, but an approach that I believe will work. As you say in the comments, each of the numbers in $M$ corresponds to a nine position vector with each position being the powers of $2,3,5,\ldots 23$ in the factorization of the number reduced $\bmod 4$. We are looking for four vectors that sum to the zero vector when each entry is reduced $\bmod 4$.
Let us concentrate on the first position in the vector. There are $2001 \choose 4$ ways to choose a four element subset of $M$. If the numbers in $M$ are distributed among the four residues, the sums will be (almost) equidistributed among $0,1,2,3$, so $\frac 14$ of the sums will be zero. Looking at all the entries in the vector we expect ${2001 \choose 4}\frac 1{4^9} \gt 2\ 500\ 000$ sums to be zero in all entries.
To avoid the equidistribution we can have all the elements of $M$ in two classes. If half have entry $0$ and half have entry $1$ in a position, the only way to get a sum of zero is to select all four with the same entry. This is only $\frac 18$ of the sets of four but you still get ${2001 \choose 4}\frac 1{8^9}\approx 4962$ sums to the zero vector.
To make this solid, let there be $a$ numbers with first entry $0, b$ with first entry $1, c$ with first entry $2,$ and $d$ with first entry $3$. You have $a+b+c+d=2001$. To get a sum of $0$ you can select four of the same, giving ${a \choose 4}+{b \choose 4}+{c \choose 4}+{d \choose 4}$ sets, or two with residue $1$ and two with residue $3$ giving ${b \choose 2}{d \choose 2}$ sets, or a number of other possibilities. You need to show that at least $\frac 1{20}$ of the sets sum to zero because $20^9 \lt {2001 \choose 4}$