Can the transpose operation on $GL_n(k)$ ever be expressed as conjugation by some element of $S_n$, identified as the group of permutation matrices? That is, does there exist $\sigma\in S_n$ such that $A^T=\sigma A\sigma^{-1}$ for all $A$?
I'm doubtful, because the tranpositions in $S_n$ act on the right by swapping columns, and act on the left by swapping rows, hence any permutation matrix does some sequence of such swaps. So I don't see a way to flip a column across the main diagonal using just these types of moves, since all the entries in a given column will stay together (as possibly a different column, and in a different "vertical" order after swapping rows around.)
To see why this is impossible, consider a matrix all of whose entries are distinct, for example $A=(2^i(2j+1))_{i,j}$.
If $B=\sigma A\sigma^{-1}$ leaves $a_{ii}$ unchanged (i.e. $b_{ii}=a_{ii}$), this means that $\sigma$ fixes $i$.
So if $\sigma A\sigma^{-1}$ leaves the diagonal unchanged, then $\sigma$ must be the identity.