Consider the PDE with Cauchy data
$\frac{\partial u}{\partial t}=\frac{\partial u}{\partial x}, ~~ t>0, x \in \mathbb{R}$
$u(0)=v$
Then with $X=L^{2}(\mathbb{R}),$ if we choose $ A \phi = \frac{\partial u}{\partial x} $ with domain $D(A)=H^{1}(\mathbb{R})$, we can convert our PDE into semigroup setting and check the conditions of Hille Yosida Theorem or Lumer Philips Theorem to know whether $A$ will generate a semigroup or not. But I want to know whether we can convert every PDE into semigroup setting or we need some condition on PDE with given initial and boundary data.
If, in your Cauchy setup, on a Banach space $X$, the unbounded linear operator $(A, D(A))$ generates a strongly continuous semigroup (the semigroup $C^0$) then yes you can transform it.