Can we use Cardano's method if the coefficients of the equation is not real?

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Can we use Cardano's method if the coefficients of the equation is not real?

If yes, is it done the same way? If no, how can we solve such equations.

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Yes. Actually, Cardano's formula works on any field whose characteristic is neither $2$ nor $3$ and on which every number has a square root and a cube root.

Here is an example (over $\mathbb C$). Consider the equation$$x^3-13ix-15+15i=0.\tag1$$Then$$\frac{(-15+15i)^2}4+\frac{(-13i)^3}{27}=-\frac{1\,681}{54}i=\left(\frac{41}{6\sqrt3}-\frac{41}{6\sqrt3}i\right)^2.$$Now, consider the numbers$$-\frac{-15+15i}2+\left(\frac{41}{6\sqrt3}-\frac{41}{6\sqrt3}i\right)\tag2$$and$$-\frac{-15+15i}2-\left(\frac{41}{6\sqrt3}-\frac{41}{6\sqrt3}i\right).\tag3$$It turns out that a cube root of $(2)$ is$$1+\frac{5\sqrt3}6i+\left(\frac12-\frac{2\sqrt3}3\right)i\tag4$$and that a cube root of $(3)$ is$$1-\frac{5\sqrt3}6i+\left(\frac12+\frac{2\sqrt3}3\right)i;\tag5$$besides, the product of these cube roots is $\frac{13i}3$. So, by Cardano's formula, $(4)+(5)$ should be a root of $(1)$. And it is: $(4)+(5)=2+i$ and you can check that $2+i$ is indeed a root of $(1)$.