Assume ZFC. Let $B\subseteq\mathbb R$ be a set that is not Borel-measurable. Clearly, $B$ must be uncountable, since countable sets are always Borel being a countable union of measurable singletons.
Question: can one conclude that $B$ necessarily has the cardinality of the continuum without assuming either the continuum hypothesis or the negation thereof?
A possibly related result is that any $\sigma$-algebra that contains infinitely many sets must necessarily have at least the cardinality of the continuum. This result is independent of the continuum hypothesis.
No, you can't make those inferences. The Borel sets satisfy the continuum hypothesis. Namely any uncountable Borel set has necessarily the cardinality of the continuum.
If $B$ is not Borel measurable, in particular it is not a Borel set. All you can conclude about it is that it is uncountable. If the continuum is large, and $B$ is any cardinality between $\aleph_0$ and $2^{\aleph_0}$ then it is not Borel; and on the other hand there are plenty of non-Borel measurable (and not even Lebesgue measurable sets) of size continuum, for example Vitali sets.
In fact even if you replace Borel by Lebesgue you can't say much more. Martin's axiom implies that any set of size $<2^{\aleph_0}$ has Lebesgue measure zero, and in particular each non-measurable set must have size continuum. On the other hand adding an uncountable number of Random reals to any model of $\sf ZFC+GCH$ will add a non-Lebesgue measurable set of size $\aleph_1$, while possibly blowing up the continuum to be much larger. (Note that Random reals are a technical set theoretic term, not just "arbitrary reals chosen at random".)