I think this is probably known/easy, but I can't solve it.
Consider the set $S=\{1,2,\ldots, n\}$, and let $a<b<n$. What is the minimum number $f(a,b)$ such that there exist $f(a,b)$ subsets of $S$ of size $a$ for which any subset of $S$ of size $b$ contains at least one of the chosen subsets.
Clearly $f(a,b)\leq \dbinom{n}{a}$, the number of subsets of $S$ of size $a$. (Choosing all subsets certainly satisfies the condition.)
Edit: Please see here for further discussion.
Revised: We can at least get a somewhat better upper bound.
Suppose that $B\subseteq S$ with $|B|=b$. For $k=0,\ldots,a-1$ there are $\binom{b}k\binom{n-b}{a-k}$ subsets $A$ of $S$ such that $|A|=a$ and $A\nsubseteq B$, so there is a family of
$$\sum_{k=0}^{a-1}\binom{b}k\binom{n-b}{a-k}$$
subsets of $S$ of cardinality $a$, none of which is a subset of $B$. Every other $a$-subset of $S$ is a subset of $B$. Thus,
$$f(a,b)\le 1+\sum_{k=0}^{a-1}\binom{b}k\binom{n-b}{a-k}\;.$$
Note that $\binom{b}k\binom{n-b}{a-k}=0$ if $k<0$ or $k>a$, so
$$\begin{align*} \sum_{k=0}^{a-1}\binom{b}k\binom{n-b}{a-k}&=\sum_k\binom{n}k\binom{n-b}{a-k}-\binom{b}a\binom{n-b}0\\ &=\binom{n}a-\binom{b}a \end{align*}$$
by Vandermonde’s identity. Finally, then,
$$f(a,b)\le\binom{n}a-\binom{b}a+1\;.$$
Added1: Of course, I did this the hard way: $S$ has $\binom{n}a$ subsets of cardinality $a$, $\binom{b}a$ of which are subsets of $B$, so it has $\binom{n}a-\binom{b}a$ that are not subsets of $B$.
Added2: This upper bound is definitely not $f$, however. Take $n=5,a=2$, and $b=3$, and consider the family
$$\left\{\{1,2\},\{3,4\},\{1,5\},\{2,5\}\right\}$$
of two-element subsets of $S=\{1,2,3,4,5\}$. If $B$ is a three-element subset of $S$ that contains neither $\{1,2\}$ nor $\{3,4\}$, then $5\in B$, and since $\{3,4\}\nsubseteq B$, it’s clear that $B\cap\{1,2\}\ne\varnothing$ and hence that $B$ contains either $\{1,5\}$ or $\{2,5\}$. Thus, for $n=5$ we have $f(2,3)\le 4$. In fact $f(2,3)=4$. If we $\mathscr{A}$ is a collection of two-element subsets such that every three-element subset of $S$ contains a member of $\mathscr{A}$, we may assume that $\{1,2\}\in\mathscr{A}$. Now let $B$ be a three-element subset of $S$ such that $B\cap\{1,2\}=\{1\}$; if $B$ is to contain a member of $\mathscr{A}$, we must have $B\setminus\{1\}\in\mathscr{A}$. But there are $\binom32=3$ possibilities for $B\setminus\{1\}$, so $|\mathscr{A}|\ge 4$.