$$ \int_0^1 \frac{1 + 3x +5x^3}{\sqrt{x}}\ dx$$
My idea for this was to break each numerator into its own fraction as follows
$$ \int_0^1 \left(\frac{1}{\sqrt{x}} + \frac{3x}{\sqrt{x}} + \frac{5x^3}{\sqrt{x}}\right)dx$$
$$ \int_0^1 (x^{-1/2} + 3x^{1/2} +5x^{5/2})\ dx $$
$$ \int_0^1 2x^{1/2} + 2x^{3/2} + \frac{10}{7}x^{7/2} $$
Not really sure where to go from there. Should I sub 1 in for the x values and let that be the answer?
It looks like you've already done the integration correctly, but forgot to take off the integration sign. The last line should be
$$\left[2x^{1/2} + 2x^{3/2} + \frac{10}{7}x^{7/2} \right]_0^1$$
which you can evaluate by substituting $x=1$ and $x=0$, and subtracting.
You asked whether you should substitute $x=1$: this will happen to give you the right answer, but only coincidentally, because the expression becomes $0$ when $x=0$.