When describing sets of points in the complex plane such as $|2z-i| =4$ would it be correct to describe the set exactly as we would in the $x,y$ plane?
For instance, Letting $z=x+iy$ for some $x,y \in \mathbb{R}$
yields the equation $x^2+(y-\frac{1}{2})^2=4$
And would it be correct to say this is the circle in the complex plane described by $x^2+(y-\frac{1}{2})^2=4$
I would say, rather, that this is the circle in the complex plane analogous to $\displaystyle x^2+\left(y-\frac{1}{2}\right)^2=4$.
The reason is, $\left |z-\frac{i}{2}\right|=2$ is well understood to mean a circle with radius $1$ and center $z=\frac{1}{2}$, and that the complex plane, as you note, uses $z$ instead of $x$ and $y$.
(Distance from center = radius)