$A$ and $B$ are two $n\times n $ real matrices, $AB=BA$. Can we conclude that
$$ \det \Big(A^2+B^2\Big)\ge \det(2AB) $$
is right?
Well, the inequality is interesting. if $A,B$ are upper triangular matrices, it is obvious right. If $AB\ne BA$, $ \det \Big(A^2+B^2\Big)\ge \det(AB+BA) $ is wrong.
The answer is NO. Take for example $A=I_2$ and
$$ B=\left(\begin{array}{cc} 0 & 1 \\ -1 & 0 \end{array}\right) $$
We then have $B^2=-I_2$, $A^2+B^2=0$ and $2AB=2B$, so ${\sf det}(A^2+B^2)=0$ and ${\sf det}(2AB)=4$.