$A,B$ are two $2\times 2$ real matrices, then $$\det(A^2+AB+B^2)\geq\det(AB-BA)$$
The inequality is equivalent to the following problem: Let $X=A+\dfrac{B}{2},Y=-\dfrac{B}{2}$
$$\det[(X-Y)(X+Y)-2(X^2+Y^2)]≥4\det(XY-YX)$$
http://www.artofproblemsolving.com/Forum/viewtopic.php?f=353&t=588819
$\square$ Since for any $2\times 2$ matrix $M$ one has $$2\operatorname{det}M=\left(\operatorname{Tr}M\right)^2-\operatorname{Tr}M^2,\tag{1}$$ the inequality we want to prove is equivalent to \begin{align}\left(\operatorname{Tr}(A^2+B^2+AB)\right)^2&\geq \operatorname{Tr}\left(\left(A^2+B^2+AB\right)^2-\left(AB-BA\right)^2\right)=\\ &=\operatorname{Tr}\left(A^4+B^4-ABAB+2A^3B+2AB^3+4A^2B^2\right). \tag{2}\end{align} On the other hand, using (1) to rewrite the inequality proved here (mentioned in the comments) and replacing therein $B\rightarrow -B$, we obtain exactly the same inequality (2). $\blacksquare$