Determination of functional dependence

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How in general can we find a functional relationship between two functions

$$ u(x,y) ~, v(x,y)~$$

when Jacobian

$$\begin{vmatrix} u_x & u_y \\ v_x & v_y \end{vmatrix}$$

vanishes? i.e., what pde/ode can be used to find the dependence or link equation?

How does it change for three functions and three variables?

Appreciate all help.