Can we find a Zariski open subset of $\mathbb{C}^n$ for some $n\ge 1$ which is not connected?
If $n=1$, this is not possible, since Zariski open subsets of $\mathbb{C}$ are just complements of finite sets.
Definition. A subset $U\subseteq\mathbb{C}^n$ is Zariski-open if its complement $\mathbb{C}^n-U$ is a zero set of polynomials $p_1,\ldots,p_k\in\mathbb{C}[x_1,\ldots,x_n]$.
No.
In the usual topology, this is because if $U$ is connected of dimension $n$ and $Z \subset U$ is of real codimension at least two then $U \backslash Z$ is connected.
In the Zariski topology, something is stronger : $U$ is irreducible since $\Bbb C^n$ is, in particular connected.