We can embed $M_{n}(\mathbb C)$ into $M_{2n}(\mathbb R)$ via $$Z=X+iY \mapsto \pmatrix{X& Y \cr -Y& X}, $$ where $X,Y \in M_{n}(\mathbb R)$. It can be seen that this embedding is an injective ring homomorphism that sends the multiplicative identity of $M_n(\mathbb{C})$ to the multiplicative identity of $M_{2n}(\mathbb{R})$.
Does this embedding also send $\text{GL}_{n}(\mathbb C)$ into $\text{GL}_{2n}(\mathbb R)$? Namely how do I conclude from $$\det (X+iY)\ne 0$$ that $$\det \pmatrix{X& Y \cr -Y& X}\ne 0\,?$$
This is immediate from the fact that your embedding is a ring homomorphism. If $X+iY$ is invertible with inverse $U+iV$, then $\begin{pmatrix}U & V \\ -V & U\end{pmatrix}$ is inverse to $\begin{pmatrix}X & Y \\ -Y & X\end{pmatrix}$, and in particular $\begin{pmatrix}X & Y \\ -Y & X\end{pmatrix}$ is invertible.