How to calculate that integral? I have no idea what substitution to use. I think polar coordinates will be needed here.
$$\displaystyle \int_{-\infty}^{\infty} \int_{-\infty}^{\infty}{ {{1}\over{2\pi}} e^{{{-1}\over{2}}(4x^2-2xy+3y^2)} ~\mathrm dx \mathrm dy}$$
Hint
First prove that your integral converges. Then $$\frac{1}{2\pi}\iint_{\mathbb R^2}e^{-\frac{1}{2}(4x^2-2xy+3y^2)}\,\mathrm d x\,\mathrm d y=\lim_{n\to \infty }\iint_{\mathcal B(0,n)}e^{-\frac{1}{2}(4x^2-2xy+3y^2)}\,\mathrm d x\,\mathrm d y,$$ where $\mathcal B(0,n)=\{(x,y)\mid x^2+y^2\leq n\}$. Using polar coordinates allow you to conclude.