Let $(X, \mathcal O_X)$ be an affine variety (ringed space which is isomorphic to a closed subset of $k^n$). An $F$-structure on $(X, \mathcal O_X)$ is defined (Springer, Linear Algebraic Groups) to be an $F$-structure $F[X]$ on $k[X]$ (which gives us a subtopology on $X$ of $F$-open sets), along with a collection of $F$-subalgebras $\mathcal O_X^F(U)$ of $\mathcal O_X(U)$, for each $U$ $F$-open in $X$, such that the natural $k$-algebra homomorphism $$k \otimes_F \mathcal O_X^F(U) \rightarrow \mathcal O_X(U)$$ is an isomorphism.
Springer claims "The proof of (the proposition that says that the ring of regular functions $\mathcal O_X(X)$ is really just the ring $k[X]$ of polynomial functions $X \rightarrow k$) carries over" and gives us that $F[X] = O_X^F(X)$." That's fine, I'll verify what he claims later. My question is about what he says next "We conclude that affine $F$-varieties and their morphisms can be described in algebraic terms." What does he mean here?
As I had to deal with some similar questions lately, I thought I tell you about my understanding of Springer's words.
Note that Springer uses the phrase 'can be described in algebraic terms' not only in the context of affine $F$-varieties but also a little bit earlier when he talks about affine $k$-varieties and their morphisms (without any $F$-structure). I believe what he is talking about here is that if $X$ is an affine $k$-variety, then all the information about $X$ is contained in $k[X]$. As a topological space, it is the maximal spectrum of $k[X]$ with the Zariski topology. Moreover, the structure sheaf $\mathcal{O}_X$ is uniquely determined by $\mathcal{O}_X(X) \cong k[X]$, as we have $\mathcal{O}_X(D(f)) \cong k[X]_f$ for all $f \in k[X]$ and the $D(f)$ form a basis for the Zariski topology.
As Springer explains, we can also identify morphisms $X \to Y$ of affine $k$-varieties with morphisms $k[Y] \to k[X]$ of $k$-algebras in a canonical way. Putting things together, we see that there is no geometry left in our description of affine $k$-varieties. We could even say an affine $k$-variety is an affine $k$-algebra and morphisms between such varieties are just the morphisms of $k$-algebras in opposite order. In terms of category theory, we have an equivalence between the category of affine $k$-varieties and the category opposite to the category of affine $k$-algebras.
Furthermore, not much changes when we consider $F$-structure. If $X$ is an affine $k$-variety with an $F$-structure, then this $F$-structure is already uniquely determined by $F[X]$. In fact we have to have $\mathcal{O}_X(D(f))(F) \cong F[X]_f$ for all $f \in F[X]$ and the $D(f)$ again form a basis for the $F$-topology.
Just like before, the $F$-morphisms $X \to Y$ correspond to the $F$-algebra homomorphisms $F[Y] \to F[X]$. And again, all geometry needed to describe affine $F$-varieties vanishes. That is, all we need to know about an affine $F$-variety $X$ are the algebras $k[X]$ and $F[X]$ and $F$-morphisms can be identified with algebra homomorphisms in the opposite direction.
I believe what Springer wants to say is simply that we are able to interpret all geometric aspects of the situation in terms of algebras and their morphisms.
Edit: To see that the $F$-structure $F[X]$ of $k[X]$ determines the affine $F$-variety structure, we only have to show $\mathcal{O}_X(D(f))(F) \cong F[X]_f$ for all $f \in F[X]$. We have $F[X] = \mathcal{O}_X(X)(F)$, so we have restriction maps $F[X] \to \mathcal{O}_X(D(f))(F)$ for any $f \in F[X]$. We may thus consider $f \in \mathcal{O}_X(D(f))(F)$. Notice that multiplication with $f$ is a linear map $\mathcal{O}_X(D(f))(F) \to \mathcal{O}_X(D(f))(F)$ which becomes an isomorphism after tensoring with $k$. Hence it was an isomorphism to begin with. But then $f$ is invertible in $\mathcal{O}_X(D(f))(F)$ and so we have a map $F[X]_f \to \mathcal{O}_X(D(f))(F)$ which becomes an isomorphism after tensoring with $k$, and so again it is an isomorphism itself.