Find diagonalizing matrix when transformations of submatrices are already known.

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I have currently a problem with a 8x8 matrix and maybe someone knows a neat trick how to solve this in an elegant way.

I have an 8x8 matrix consisting of four 4x4 submatrices:

$M=\begin{pmatrix} A & B \\ B^{\dagger} & -\tilde{A} \end{pmatrix}$

So $A$ and $-\tilde{A}$ have the same structure with different values. All submatrices are hermitian and thus $M$ is also hermitian.

Now: I already know the analytic results for the diagonalization of each submatrix, i.e. I already have all $U_X$ for which I get the diagonal matrix $D_X$:

$ D_X = U_X^{\dagger} X U_X$ for $X=A,B,\tilde{A}$.

So the question: outgoing from the 4 transformations which diagonalize the submatrices, is there a smart way to construct the transformation which diagonalizes $M$?

Edit: yes, $A$,$B$ and $\tilde{A}$ are hermitian Edit2: Notation changed for clarity