$$A= \left\{\frac{m}{n}+\frac{4n}{m}:m,n\in\mathbb{N}\right\}$$
Since $m,n\in \mathbb{N}$, infimum is zero because $m,n$ both are increasing to infinity. Then the supremum is $5$ when $m,n$ are equal to $1$.
But I don't think my approach is right. Can someone give a hit or suggestion to get the right answer? Thanks.
Your answer isn't good. We see that $m/n+n/m=\frac{m^2+n^2}{mn}\geq 2$ by $MA\geq MG$. So $m/n+4n/m=m/n+n/m+3n/m\geq 2+3n/m$. Take $m=1$ the expression is ilimited. $\sup(A)=\infty$. Since $E=m/n+4n/m=\frac{m^2+4n^2}{nm}\geq 4$ by $MA\geq MG$ we have the infimumm is 4 and holds always that m=2n.