Let $U$ and $V$ be the points in $\mathbb{R}^4$ with position vectors $u=(1, 2, -1, -3)$ and $v=(1, 0, -2, 3)$.
Find the distance from $U$ to the $span(v)$.
I'm not quite sure if the definition $span(v)$ that I know was right so I decided to use what I know which is $span(v)=t(1, 0, -2, 3)$ wherein to find the distance, I find the norm of $span(v)$-$U$. However, I am not quite sure if I'm going the right way with this.
If you don't know, then you should not decide it for yourself, but check your notes!
Nevertheless, your assuption was right. For a set $A$ we define $$ span(A)=\left\{\sum_{k=1}^n \alpha_ka_k~:~n\in\mathbb N, \alpha_k\in\mathbb R,~a_k\in A\right\}. $$ In your case, the set contains just the vector $v$, so you can simplify it to $$ span(v)=\{tv~:~t\in\mathbb R\}. $$
The minimal distance between $u$ and $span(v)$ is the minimum of $f(t)=d(u,tv)$ where $d$ is your metric. If you use the euclidean metric, then you get $f(t)=\|u-tv\|_2$. But to simplify the computation, you can consider \begin{align} g(t)&=(f(t))^2=\|u-tv\|_2^2=\|(1-t,2,-1-2t,-3-3t)\|_2^2\\ &=(1-t)^2+2^2+(-1-2t)^2+(-3-3t)^2 \end{align} So, $g$ is a quadratic polynomial. The square root of the minimum of $g$ is your minimal distance, you are looking for. The rest is up to you.