Let $A$ and $B$ be two sets for which the following applies:
$A = \{x: \text{GCD(}x,12) = 1\}$
$B = \{x: x\ \text{is a prime}\}$
Find the lowest value of $x$ so that $x \in (A \setminus B)$.
$x \in A \setminus B$ means that $x \in A$ and $x \notin B$. So, $x$ is not a prime, and its greatest common divisor with 12 is 1...
How to solve?
Answer the literal question of "How to solve?" rather than "What is the answer?", I'd expect something like the following approach:
$$A = \{1,5,7,11,13,17,...\} \\ B = \{2,3,5,7,11,13,...\} $$
Clearly $1$ is the solution, but assuming for a moment that the question had forbidden it, we can think about the structure of the sets...
Ideally here we'd see that the alternative view of $A$ is that it consists of all numbers coprime to both 2 and 3 - that is, it excludes only multiples of $2$ and $3$, and then link this to our knowledge of sieve methods for finding primes, which exclude multiples of all earlier members of the set of primes.
This gives us a characterization of $(A \setminus B)$: it is $\{1\}$ along with all composites with smallest prime factor $\ge 5$. And the second smallest member of that set is of course $25$ as already discussed.