Find the number of real roots of the derivative of $f(x)=(x-1)(x-2)(x-3)(x-4)(x-5)$

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Find out the number of real roots of equation $f'(x) = 0$, where $$f(x)=(x-1)(x-2)(x-3)(x-4)(x-5)$$

How can I differentiate this function without expanding it to the polynomial form. Am I underestimating some theory of equation concept associated with it? (I know the product rule approach and solving by simplifying but I want to know is there any other way to solve it)

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This is a question about Rolle's Theorem.
The derivative is a polynomial of degree 4, so it has at most four zeros.
Can you explain why it has exactly four zeros.

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You can extend the idea of the product rule. You already know that if $y=f\times g$ then $y'=f'\times g+f\times g'$. If you have more functions multiplied then we get, if:

$$y=f_1\times f_2\times f_3\times...\times f_n$$

then

$$y'=f'_1\times f_2\times f_3\times...\times f_n+f_1\times f'_2\times f_3\times...\times f_n+f_1\times f_2\times f'_3\times...\times f_n+...+f_1\times f_2\times f_3\times...\times f'_n$$

Hence for your question you get:

$$y'=(x-2)(x-3)(x-4)(x-5)+(x-1)(x-3)(x-4)(x-5)+(x-1)(x-2)(x-4)(x-5)+(x-1)(x-2)(x-3)(x-5)+(x-1)(x-2)(x-3)(x-4)$$

Note that this now won't nicely factorize so you'd need to expand from here... $$$$ However none of this is needed to answer your question. As $f(x)$ is of degree 5 then the derivative will be of degree 4. If you think about the graph of $f(x)$ there will not be any repeated roots of $f'(x)$ so there will be 4 solutions.