There are many MSE posts about how to define a cross product in $\mathbb{R^4}$. It is impossible to define a cross product of two vectors in $\mathbb{R^4}$, since there are infinitely many directions perpendicular to those two vectors, and we don't know which direction to choose. However, If we are given THREE vectors $A,B,C$, it is possible to find a unique direction perpendicular to this three vectors, if $A,B,C$ are independent. However, finding this perpendicular vector involves solving a system of equations.
So my question is:can we define a Quasi Cross Product $\{A,B,C\}$ on $\mathbb{R^4}$, so that we can find a direction perpendicular to $A,B,C$ without solving a system of equations?
You have the "same" determinant formula. If $\vec{a} = (a_1,a_2,a_3,a_4)$, similarly for $\vec{b}$ and $\vec{c}$, then $$\vec{a}\times\vec{b}\times \vec{c} = \begin{vmatrix} \vec{e}_1 & \vec{e}_2 & \vec{e}_3 & \vec{e}_4 \\ a_1 & a_2 & a_3 & a_4 \\ b_1 & b_2 & b_3 & b_4 \\ c_1 & c_2 & c_3 & c_4\end{vmatrix},$$where $(\vec{e}_1,\ldots,\vec{e}_4)$ is the standard basis for $\Bbb R^4$. This does not require solving a system. Example: $$(1,1,0,0)\times (0,1,1,0) \times (0,0,1,1) = \begin{vmatrix} \vec{e}_1 & \vec{e}_2 & \vec{e}_3 & \vec{e}_4 \\ 1 & 1 & 0 & 0 \\ 0 & 1 & 1 & 0 \\ 0 & 0 & 1 & 1\end{vmatrix} = (1,-1,1,-1).$$