Four letters are picked from the word BREAKDOWN. What is the probability that there is at least one vowel among the letters?

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I know that the right answer is 0.881 but i'm not sure how to get there.

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In the easy-to-verify form: $$ 1-\frac{\binom{6}{4}\cdot\binom{3}{0}}{\binom{9}{4}} $$

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Use the complement rule. $P(\text{at lest one vowel}) = 1 - P(\text{no vowels})$. You have 6 non-vowels and 3 vowels. What can you do with this? The easiest thing to do is to draw a probability tree.