If I understand the continuum hypothesis (and its undecidability) correctly, then one can safely assert the existence of some set $A$ whose cardinality is between that of the integers and that of the real numbers, and this assertion will not cause a contradiction within ZFC set theory.
Have such sets ever been useful within mathematics or physics? I'll leave "useful" up to your own interpretation, but here are some examples of what I mean:
The assumption that there exists a type of number whose square is $-1$ led to complex analysis, which has been useful in both pure math and applied physics.
The rejection of Euclid's 5th postulate led to non-Euclidean geometry, which was also useful in both math and physics.
Some starting criteria for "useful" might be:
- Launching a new field of math
- Shedding new light on existing fields of math
- Helping prove something that was already an open question
- Playing any role in theoretical physics or some other field
In both cases this was not an assumption, but a definition.
You define $\Bbb C$ as the quotient ring $\Bbb R[X]/{\left<X^2+1\right>}$ and observe that in this structure, $X$ is an element with square $-1$.
Similarly, non-Euclidean geometry is not assumed, it is observed in frameworks defined within the ZFC axioms.
An example of a set with cardinality between $\omega$ and $\mathfrak{c}$, by definition, cannot be constructed within ZFC. You can always assume its existence in a non-constructive manner, but then there is very little you can actually do with it. Or you could possibly construct it if you forgot about ZFC and worked in a suitable set of axioms, but then again it would not be useful to the ZFC community.