There are actually two questions here. Neither of these is a homework question.
Let $\text{hom}(\mathfrak{A},\mathfrak{B})$ (not to be confused with the Hom functor) be the class$^0$ of homomorphisms between two structures (of the same signature) $\mathfrak{A}=(A,(f_i)_{i\in I})$ and $\mathfrak{B}=(B,(g_j)_{j\in J})$ $^1$. If the objects (domains) of $\mathfrak{A}$ and $\mathfrak{B}$ ($A$ and $B$, respectively) are sets, then $\text{hom}(\mathfrak{A},\mathfrak{B})$ is a set.
Question 1
Given two arbitrary structures $\mathfrak{A}$ and $\mathfrak{B}$ over known sets ($A$ and $B$, respectively), what is the cardinality of $\text{hom}(\mathfrak{A},\mathfrak{B})$?
My work:
Using the product convention of functional analysis (a summary of which can be found here), it is clear that...
$$\text{hom}(\mathfrak{A},\mathfrak{B})\subseteq\prod_{i\in A}B\cong B^{|A|}$$
...whence,...
$$|\text{hom}(\mathfrak{A},\mathfrak{B})|\le|B|^{|A|}$$
The lower bound of $|\text{hom}(\mathfrak{A},\mathfrak{B})|$ is obviously $0$, so $0\le|\text{hom}(\mathfrak{A},\mathfrak{B})|\le|B|^{|A|}$.$^2$ This is not much help on its own, though.
It is not generally true that the set of functions from $A$ to $B$ is the set of homomorphisms from $\mathfrak{A}$ to $\mathfrak{B}$; but I'm not sure how to reduce the set of functions to just the set of homomorphisms, which leads me to my second question.
Question 2
Given two arbitrary structures $\mathfrak{A}$ and $\mathfrak{B}$ over known sets ($A$ and $B$, respectively), characterize the set $\text{hom}(\mathfrak{A},\mathfrak{B})$.
I don't really have a good method for explicitly defining the set of homomorphisms between two structures - at least, not in a way that would let me construct an explicit bijection from the set of homomorphisms to, say, an ordinal. It might be the case that the set of functions from $A$ to $B$ has a cardinality of $\aleph_0^{\aleph_0}$ $^3$ while the set of homomorphisms has a cardinality of $\aleph_0$ - but I wouldn't know that unless I was able to enumerate the elements of $\text{hom}(\mathfrak{A},\mathfrak{B})$ - which I can't do because I have no idea what it looks like.
Footnotes
$^0$ "class" here is meant roughly in the sense that it has been used in NBG, Principia Mathematica or the metamath language - e.g. a set is a class, a proper class is a class, a collection of proper classes is a class, etc. but a proper class is not a set, etc.
$^1$ I am ignorant of structures with an uncountable set of operations and/or relations, unless these are more common than I think, you can assume that $I$ and $J$ are countable.
$^2$ The smallest possible set containing all homomorphisms between arbitrary structures is the empty set, since there might not be any homomorphisms between them. $\text{hom}(\mathfrak{A},\mathfrak{B})=\emptyset\implies |\text{hom}(\mathfrak{A},\mathfrak{B})|=0$
$^3$ Depending on the choice of theory and the acceptance or rejection of the continuum hypothesis this may variously evaluate to $\mathfrak{c}$, $2^{\aleph_0}$, or $\aleph_1$. I'm leaving it as $\aleph_0^{\aleph_0}$ because the details of this aren't relevant to the question.
Let $p(x_1,\dots,x_n)$ be your favorite polynomial with integer coefficients. Consider the rings $\mathfrak{A} = \mathbb{Z}[x_1,\dots,x_n]/(p)$ and $\mathfrak{B} = \mathbb{Z}$. Then the set of ring homomorphisms $\text{Hom}(\mathfrak{A},\mathfrak{B})$ is in bijection with the set of integer solutions to $p = 0$. Explicitly, if $f\colon \mathbb{Z}[x_1,\dots,x_n]/(p)\to \mathbb{Z}$ is a ring homomorphism, then $p(f(x_1),\dots,f(x_n)) = 0$, and for any tuple $(a_1,\dots,a_n)\in \mathbb{Z}^n$ such that $p(a_1,\dots,a_n) = 0$, there is a unique ring homomorphism $f\colon \mathbb{Z}[x_1,\dots,x_n]/(p)\to \mathbb{Z}$ such that $f(x_i) = a_i$ for all $1\leq i\leq n$.
Now understanding the integer solutions to the Diophantine equation $p(x_1,\dots,x_n) = 0$ for various polynomials $p$ is a notoriously hard kind of problem in number theory (see e.g. Fermat's last theorem!). There's definitely no simple criterion for determining, for example, whether or not $\text{Hom}(\mathfrak{A},\mathfrak{B})$ is finite, or even nonempty. In fact, in their solution to Hilbert's tenth problem, Martin Davis, Yuri Matiyasevich, Hilary Putnam and Julia Robinson proved that this problem is computationally undecidable.