Up to isomorphism.
For instance, the group axioms are verified by an infinite number of non-isomorphic algebraic structures. But the Peano axioms, I think (my proof may lack some formality due to my lack of in depth knowledge of logic and foundations, but I think it's rigorous enough that someone more knowledgeable could make it into a formal proof) uniquely determine $\mathbb{N}$: any two structures that satisfy the Peano axioms must be isomorphic.
One thing I noted is that the axioms for standard classes of structures (rings, groups etc - all of which have many non-isomorphic instances) are always of the form:
$$(\forall a_1...a_n\in A)\ \phi(a_1...a_n) = \psi(a_1...a_n)$$
Where $\phi$ and $\psi$ are functions "defined in terms of" the structure operations. On the other hand, the Peano axioms include axioms of other forms, notably the ones governing the successor operations. Could this be relevant?
Are there any results describing the relationship between an axiom set, and the number of non-isomorphic structures verifying it?
If there is a sentence specifying the cardinality of the model to be a finite $n$ then you can write an axiom schema which ensures its uniqueness.
But if a [consistent] first-order theory does not have finite models then it has models in every cardinality. This follows from the Lowenheim-Skolem theorems. Clearly, then, those models are not isomorphic.
Sometimes, though, a theory has a unique model in a particular cardinality, this is called categoricity. There are several tests whether or not a theory is categorical in any cardinality, but those usually require some more knowledge in model theory.
It is not a coincidence that model theory and algebra have a large intersection in modern mathematics.