I started by showing that $$ k\times0.25^{2^{k+2}-2^k} =k\frac{0.25^{2^{k+2}}}{0.25^{2^k}}$$
$$= k \frac{({0.25^{2^k}})^4}{{0.25^{2^k}}}$$
$$=k(0.25^{2^k})^3 $$
Then I don't know how to proceed. I suspect the $(0.25^{2^k})^3$ goes to $0$ much faster than $k$ goes to infinity but don't know how to prove it.
Use L'Hospital rule: $$\lim_\limits{k\to\infty} \frac{k}{4^{3\cdot 2^k}}=\lim_\limits{k\to\infty} \frac{1}{3\cdot 4^{3\cdot 2^k}\cdot \ln4 \cdot 2^k \cdot \ln2}=0.$$