For a $2\times 2$ matrix $$\begin{pmatrix}a&b\\c&d \end{pmatrix} $$ The determinant is given by $ad-bc$. And the cross product of $$\begin{pmatrix} a\\b\\0\end{pmatrix}\times \begin{pmatrix} c\\d\\0\end{pmatrix} =\begin{pmatrix} 0\\0\\ad-bc\end{pmatrix}$$
We can also note that $|a\times b|=|a|b|\sin\theta$ where $\theta$ is the angle between $a$ and $b$. Hence is there any way to relate the determinant to the equation with sine? I recently saw that $$\text{Re}(a)\text{Im}(b)-\text{Im}(a)\text{Re}(b)=|ab|\sin{\text{arg}(a/b)}$$
How would one verify/prove this?
Your last question (involving the real and imaginary parts of complex numbers) is just a restatement of the formula
$$ \left| a \times b \right| = |a| \, |b| \, \sin(\theta)$$
If $a = x+iy$ and $b=z+iw$ are complex numbers, then you can think of them as the vectors $(x,y)$ and $(z,w)$, where the real and imaginary parts are just the coordinates. Then $|ab| = |a| \, |b|$, and $\mathrm{arg}\left( a/b \right)$ is the angle between the vectors, so it is exactly the same formula. The left hand side is just the determinant formula which you wrote in your question.