\begin{vmatrix} 2 & 4 & 4 & \dots & 4 & 4 \\ 4 & 4 & 4 & \dots & 4 & 4 \\ 4 & 4 & 6 & \dots & 4 & 4 \\ \vdots & \vdots & \vdots & \ddots & \vdots \\ 4 & 4 & 4 & \dots & 2n-2 & 4 \\ 4 & 4 & 4 & \dots & 4 & 2n \end{vmatrix}
I tried to get a triangular matrix, subtracting the lines, but it did not work out
\begin{eqnarray*} \begin{vmatrix} 2 & 4 & 4 & \dots & 4 & 4 \\ 4 & 4 & 4 & \dots & 4 & 4 \\ 4 & 4 & 6 & \dots & 4 & 4 \\ \vdots & \vdots & \vdots & \ddots & \vdots \\ 4 & 4 & 4 & \dots & 2n-2 & 4 \\ 4 & 4 & 4 & \dots & 4 & 2n \end{vmatrix} \end{eqnarray*} Subtract the second row off all the other rows to get \begin{eqnarray*} \begin{vmatrix} -2 & 0 & 0 & \dots & 0 & 0 \\ 4 & 4 & 4 & \dots & 4 & 4 \\ 0 & 0 & 2 & \dots & 0 & 0 \\ \vdots & \vdots & \vdots & \ddots & \vdots \\ 0 & 0 & 0 & \dots & 2n-6 & 0 \\ 0 & 0 & 0 & \dots & 4 & 2n-4 \end{vmatrix} \end{eqnarray*} The product on the leading diagonal is $\color{red}{-2^{n+1} (n-2)!}$.