How to derive the variance of a point estimator that contains another estimator?

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I am trying to derive an variance estimator $var(\hat{\theta}(\mu,x))$ for an point estimator $\hat{\theta}(\mu,x)$, where $\mu$ is the true mean, $x$ is the data.

Now I need to replace the true mean $\mu$ with the sample mean $\hat{\mu}$. Then what is the general approach to incorporate this extra variability of sample mean $\hat{\mu}$ in computing $var(\hat{\theta}(\mu,x))$?

Any reference, comment or suggestion will be appreciated!