How to find an upperbound on the time of depopulation of an urban enviroment

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Given an urban area such as a shopping mall, is there a statistical model that estimates how often during a working day the area becomes depopulated and what is the maximum time of depopulation?

By depopulation I mean that the number of people per unit area becomes zero.

In particular I am interested to know the answer to this question: Can we say that typical urban areas are usually populated (during the working day) and there is an upper-bound for the depopulation time? any article that exposes some research regarding this subject would be useful.