If two planes are perpendicular, their normal vectors will also be perpendicular.
If a plane contains two points, it contains the line through those points; in particular its normal vector is perpendicular to the direction vector of the line.
So the desired plane's normal vector is perpendicular to $(1,-2,1)$ and $(3,-5,0)-(-2,4,3)=(5,-9,-3)$. The cross product yields such a perpendicular vector: $(15,8,1)$. So the equation of the plane is $15x+8y+z=k$, where $k$ is found by substituting either given point in: $15\cdot(-2)+8\cdot4+1\cdot3=5$. The final answer is $15x+8y+z=5$.
Two things first:
So the desired plane's normal vector is perpendicular to $(1,-2,1)$ and $(3,-5,0)-(-2,4,3)=(5,-9,-3)$. The cross product yields such a perpendicular vector: $(15,8,1)$. So the equation of the plane is $15x+8y+z=k$, where $k$ is found by substituting either given point in: $15\cdot(-2)+8\cdot4+1\cdot3=5$. The final answer is $15x+8y+z=5$.