How to find the percentage change in size for a cylinder/sphere like object?

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I have an object of more or less unknown shape and I'm trying to find the size change over time. The object is a cancer tumor and from each scan I get two numbers.

Scan 1: 3.0 x 3.6

Scan 2: 1.5 x 1.3

Eyeballing the numbers I would say it is a >50% reduction. How do I calculate this in math?