I encountered the following problem in Brualdi (Section 5.6, Problem 21):
Prove that, for all real numbers $r$ and all integers $k$,
$$\binom{-r}{k} = (-1)^k \binom{r + k - 1}{k}$$
It looks like the right hand side has the formula for choosing $k$ elements from a multiset.
$$\binom{r + k - 1}{k} = \binom{r + k -1}{k - 1}$$
I know that $\binom{n}{k} = 0$ if $n < k$, but what if $k$ is negative and $n$ is a real number. I'm not sure where to go from here.
$$\binom{-r}{k} =$$
$$ \frac {(-r)(-r-1)(-r-2)...(-r-k+1)}{k!}=$$
$$(-1)^k \frac {(r+k-1)(r+k-2)...(r+1)(r)}{k!}=$$
$$(-1)^k\binom{r+k-1}{k}$$