If $M$ and $N$ are normal subgroups of $G$ and $M \subseteq N$, $G/N$ cyclic and $|N/M|=2$ prove that $G/M$ is Abelian.
If $M$ is a subgroup of $N$, keeping in mind that $[N:M]=2$, we can get that $M \triangleleft N$. Also from Third isomorphism theorem we have: $$(G/M)/(N/M) \cong G/N$$
$G/N$ is cyclic, so $(G/M)/(N/M)$ has to be also cyclic. $G/M$ has elements of form $gM$ and $(G/M)/(N/M)$ has elements of form $gM(N/M)$ and because $N/M = \{M, nM \}$, $gM(N/M) = \{gM, gnM \}$. This is cyclic, so $n = g^k$. If $n = g^k$ then is also $m = g^l$. I am not sure what to do with this, can someone please help me?
Following Arthur's suggestion in the comments above, denote $G/M$ by $G'$ and $N/M$ as $N'$. As you've noted, $G'/N'$ is cyclic, being isomorphic to $G/N$.
Therefore, it suffices to check that every element of $N'$ commutes with every element of $G'$. Since $N'$ is normal in $G'$, for $g' \in G'$, $n_1', n_2' \in N'$, $g'n_1' = n_2'g'$. Since $N'$ is of order $2$, either $n_2' = 1$ or $n_2' = n_1'$. Suppose the former. Then $g'n_1' = g'$, hence $n_1' = 1 = n_2'$. Thus, $n_1' = n_2'$ and the elements of $N'$ commute with every element of $G'$. So $G'$ is abelian.