If we have $n + 2$ natural numbers there are always $2$ whose sum or difference is a multiple of $2n + 1.$
I tried to use the pigeonhole principle with remainder technique. If the numbers are divisible by $2n+1,$ then we have $2n$ possible remainders. However, the $n+2$ numbers will be matching $2n$ remainders and $n+2\lt2n,$ so I am stuck. Any help is appreciated!
There are $2n+1$ residue classes $\pmod {2n+1}$. If two of your numbers are in the same residue class, then (by definition) their difference is divisible by $2n+1$, so let's suppose that they occupy $n+2$ distinct residue classes.
Now remark that we can divide the classes into pairs that add to a multiple of $2n+1$, namely $(1,2n),(2,2n-1),\cdots, (n,n+1)$ with $0$ left unpaired. We note that there are $n$ pairs. Even if $0$ is one of your choices, we would still have to make $n+1$ choices from those pairs. by the pigeon hole principle, therefore, if you have $n+2$ choices you must have chosen two from the same pair, and we are done.