If $x+y=2$ is a tangent to the ellipse with foci $(2, 3)$ and $(3, 5)$, what is the square of the reciprocal of its eccentricity?
This could be done by the property, The product of perpendiculars drawn from focus to the tangent is equal to $b^2$. But I couldn't figure out where is error in my approach.

The equation of tangent used is wrong. Your formula only works when the centre of the ellipse is at the origin and the axis of ellipse is parallel to x and y axis.
In this case we use a modified version of the same as pointed out by Jan-Magnus Økland in the comments. The centre of this ellipse is ($2.5,4$) and axis of this ellipse are $-2x+y+1=0$ and $x+2y-\frac{21}2=0$
Therefore, in this case we use
$$\frac{-2x+y+1}{\sqrt5}=m\frac{x+2y-\frac{21}2}{\sqrt5}\pm\sqrt{a^2m^2+b^2}$$
Note: I thank @Jan-Magnus Økland for pointing out a major blunder in my answer.