Let us work in a class theory like NBG.
For a given first order sentence $\phi$ define $\infty\text{-spectrum}(\phi)$ to be the class of all cardinal numbers $\kappa$ for which there is a model $M$ of $\phi$ such that the cardinality of $M$ is $\kappa$. Let $\text{Card}$ be the class of all cardinal numbers. Set $\text{Card}_+:=\text{Card}\setminus \{0\}$. A subclass $S$ of $\text{Card}_+$ is said to be an $\infty$-spectrum if there is a first order sentence $\phi$ with $\infty\text{-spectrum}(\phi)=S$.
Question: Let $S$ be an arbitrary $\infty$-spectrum. Does it follow that $\text{Card}_+\setminus S$ is also an $\infty$-spectrum?
By compactness, if $\phi$ have models of arbitrarily large finite cardinality, then $\phi$ has an infinite model, and by Lowenheim-Skolem (upward and downward) you can find models of $\phi$ of any cardinality $\kappa\geq \aleph_0$.
So, one can restrict the question to $S\subseteq \mathbb{N}\setminus \{0\}$, but I have the feeling that is a complicated question.
In fact, quoting Exercise 1.4.7(c) of Marker's book "Model Theory: an introduction":
Thus, I guess the question is whether the collection of sets that are recognizable in nondeterministic exponential time is closed under complement, but that is certainly a question that I cannot answer in my huge ignorance about Turing machines.