$I=\int_{1}^{2}\frac{e^x+e^{4/x}}{x}dx$
For $ x \in (1,2), \frac{e^x+e^{4/x}}{x}>e^x$
$\Rightarrow I=\int_{1}^{2}\frac{e^x+e^{4/x}}{x}dx$ >$\int_{1}^{2}e^xdx$
$\Rightarrow I>e^2-e$
And $I<e+e^4$ by considering a rectangle
Is there a better way we can approximate the integral more efficiently by assuming some function like $e^x$ which can be understood by a highschool student?
The exact result is expressed in terms of special functions beyond such students' education. As the comments have suggested, we can numerically approximate by whatever methods the curriculum covers. To improve the approximation, divide the integration range into more strips (see e.g. here). But it's a job for a computer.