Define a knot shadow as a projection of a knot that does not indicate over- and under-crossings. So, if there are $c$ crossings, there are $2^c$ possible over/under assignments, and so that many conventional knot diagrams are consistent with the shadow.
Is it always the case that, if the knot shadow is the shadow of a true knot, that one of the knot diagrams consistent with that shadow is the trivial knot, i.e., the unknot?

Yes. Every knot has a finite unknotting number.