I know they both have the same cardinality and are not cyclic. As well, I know that both groups have the same number of finite elements.
I know of no way to disprove that they're isomorphic, but am having a hard time finding a certain isomorphism.
Any ideas would be greatly appreciated.
I’m pretty sure that U(16) is Abelian — it inherits commutativity from arithmetic mod 16. So U(16) and D4 are not isomorphic, since D4 is non-Abelian.